Monoclonal Antibody mNI-58 Inducing Morphological Changes in a Human Monocyte-Like Cell Line, U937, Stimulated with Phorbol Myristate Acetate(PMA).
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چکیده
منابع مشابه
Expression Pattern of Interferon-γ in Human Leukemic T Cell Lines Following Treatment with Phytoheamagglutinin, phorbol myristate acetate and Lipopolysaccharide
Background: As a T helper type 1 (Th1) derived cytokine, Interferon gamma (IFN-γ) is an important regulator of inflammatory immune responses. Furthermore, IFN-γ plays an essential role in defense against tumors and intracellular pathogens. This study was designed to assess the pattern of IFN-γ production in human leukemic (Jurkat and Molt-4) T cell lines in vitro. Methods: Ju...
متن کاملmonocyte-like cell line
The complement fragment C5a and its des-Arg74 derivative, C5a des Arg, are potent mediators of leucocyte chemotaxis and are thought to play an important role in the accumulation of leucocytes at sites of inflammation. Although specific receptors for C5a have been demonstrated on murine macrophages (Chenoweth et al., 1982) and human monocytes (Chenoweth & Goodman, 1983; Marder et al., 1985), mos...
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A specific surface receptor for urokinase plasminogen activator (uPA) recognizes the amino-terminal growth factor-like sequence of uPA, a region independent from and not required for the catalytic activity of this enzyme. The properties of the uPA receptor (uPAR) and the localization and distribution of uPA in tumor cells and tissues suggest that the uPA/uPAR interaction may be important in reg...
متن کاملThe binding and processing of monoclonal human IgG1 by cells of a human macrophage-like cell line (U937).
The goal of these experiments was to assess the relationship between the binding and processing of IgG by Fc-receptor-bearing cells. Cells of the U937 human macrophage-like cell line were incubated with 125I-labeled monomers, dimers, oligomers (composed of 2-4 IgG1 subunits), and HP (heavy polymers composed of 5 or more subunits per polymer) of monoclonal human IgG1 in vitro. Binding was assess...
متن کاملMonocyte-associated tissue factor is suppressed by phorbol myristate acetate.
The monocyte is the only normal circulating cell type capable of initiating blood coagulation through the expression of tissue factor. Recently isolated peripheral blood monocytes that contain no demonstrable tissue factor activity can be induced to express tissue factor activity by a number of stimulatory agents. Monocyte-associated tissue factor activity transiently increases in response to a...
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ژورنال
عنوان ژورنال: Nippon Saikingaku Zasshi
سال: 1995
ISSN: 1882-4110,0021-4930
DOI: 10.3412/jsb.50.1033